Urea (Also known as Carbamide)

Urea (Also known as Carbamide)


Quick Facts

  • Contains a selection of biological activities and is able to regulate the structure of the outer layer of the skin
  • Breaks the bonds locking away amino acids in the skin, therefore improving the overall barrier health
  • Has been formulated in skincare products for a number of decades
  • Can help soothe skin dryness and condition such as psoriasis, eczema and certain types of dermatitis

Who can use it?

Urea naturally occurs in the skin making all skin types able to use it when formulated into skincare products.

What is Urea?

Urea may sound familiar, and yes you are right, it does occur in your urine. But it does also naturally appear in your skin and is considered one of the most potent natural moisturising factors (also called NMF) These factors are vital for keeping the skin’s protective barrier functioning correctly and helping the skin remain in its healthiest state. Although urea makes up only 7% of NMF, unlike amino acids which add up to 40%, it is unique ability to act like a mild keratolytic agent which is able to break down the bonds in protein allowing more amino acids to work their way onto the surface of the outer surface, helping to improve the skin’s barrier and overall complexion. Urea is so moisturising it is able to help treat the skin with added hydration to restore balance and improve any excessive dryness and various skin conditions, such as psoriasis, eczema and certain types of dermatitis. 

Side effects of Urea?

Urea can usually be tolerated by almost all skin types. Those with hyper sensitive skin may want to consult a doctor or dermatologist to prevent any skin irritated.

Scientific Evidence

  • Pan, Michael, et al. "Urea: a comprehensive review of the clinical literature." Dermatology online journal 19.11 (2013).
  • Grether-Beck, Susanne, et al. "Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression." Journal of Investigative Dermatology 132.6 (2012): 1561-1572.
  • Lodén, Marie. "Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders." American journal of clinical dermatology 4.11 (2003): 771-788.


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